Research
Mixed
Resveratrol supplementation mimics the effects of caloric restriction by activating SIRT1, leading to metabolic and vascular benefits in obese humans.
Consider resveratrol supplementation (e.g., one month) if you are obese, as it may activate SIRT1 and improve metabolic health similar to caloric restriction. Discuss with a healthcare provider to determine appropriate dosing and safety.
ModerateSupportsMEDIUM confidence
Since 2003, resveratrol... has been identified as a potent SIRT1 activator that mimics the effect of caloric restriction... In obese humans, one month of resveratrol supplementation, in fact, induced metabolic changes, mimicking the effect of caloric restriction.
Why this rating
Based on a review of studies, including some human clinical trials, but not definitive large-scale RCTs.
Source
Oxidative Stress and Epigenetic Regulation in Ageing and Age-Related Diseases
Chiara Cencioni et al. · International Journal of Molecular Sciences · 2013
DOI 10.3390/ijms140917643
narrative_reviewCited 222×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Oxidative stress contributes to aging and age-related diseases by altering epigenetic markers, including DNA methylation and histone modifications, leading to cellular senescence and organ dysfunction.Good
- Caloric restriction extends lifespan and delays age-related decline by activating SIRT1, which deacetylates and activates eNOS to improve vascular function and reduce oxidative stress.Moderate
Related findings · Mixed
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