Research
Adherence
Exercise training can improve age-related endothelial dysfunction by reducing oxidative stress and improving the function of potassium channels (KCa) involved in endothelium-derived hyperpolarization (EDHF).
Regular exercise is beneficial for older adults as it can improve endothelial function by reducing oxidative stress and enhancing blood vessel relaxation mechanisms. Even if starting late, exercise can help recover some vascular health.
ModerateSupportsMEDIUM confidence
A decline on the responses mediated by large conductance KCa (BKCa) has been reported in coronary arteries from aged rats which can be recovered by exercise training.
Why this rating
Evidence is cited from animal models (rats) and some human observational data, but specific dosing protocols are not detailed in this review.
Source
Mechanisms Involved in the Aging-Induced Vascular Dysfunction
Mariam eEl Assar De La Fuente et al. · Frontiers in Physiology · 2012
DOI 10.3389/fphys.2012.00132
narrative_reviewCited 221×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Aging induces endothelial dysfunction primarily through reduced nitric oxide (NO) bioavailability caused by oxidative stress (superoxide scavenging NO to form peroxynitrite) and increased arginase activity, which can be partially reversed by antioxidant therapy or arginase inhibition.Good
- Chronic low-grade inflammation ('inflammaging') contributes to age-related endothelial dysfunction by increasing pro-inflammatory cytokines (TNF-alpha, IL-6) and activating NF-kB, which can be mitigated by anti-inflammatory interventions.Good
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