Research
Hormonal
Chronic low-grade inflammation ('inflammaging') contributes to age-related endothelial dysfunction by increasing pro-inflammatory cytokines (TNF-alpha, IL-6) and activating NF-kB, which can be mitigated by anti-inflammatory interventions.
Managing chronic inflammation is important for vascular health in aging. This can be achieved through lifestyle changes that reduce inflammatory markers, such as a healthy diet and regular physical activity.
GoodSupportsHIGH confidence
Normal aging ('usual aging') is associated with higher levels of cytokines, especially TNF-alpha, IL-1beta, and members of the super family of IL-6, as well as elevations of C-reactive protein (CRP) and fibrinogen that contribute to a pro-inflammatory microenvironment and facilitate the development of vascular dysfunction.
Why this rating
Supported by multiple human and animal studies cited in the review.
Source
Mechanisms Involved in the Aging-Induced Vascular Dysfunction
Mariam eEl Assar De La Fuente et al. · Frontiers in Physiology · 2012
DOI 10.3389/fphys.2012.00132
narrative_reviewCited 221×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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