Hormonal
Dietary supplementation with wheat-derived arabinoxylan oligosaccharides (AXOS) reduces body weight gain and fat mass in diet-induced obese mice by increasing satietogenic gut peptides (PYY and GLP-1) and reducing metabolic endotoxemia.
In this mouse study, wheat-derived arabinoxylan oligosaccharides (AXOS) helped reduce weight gain and fat mass when added to a high-fat diet. This effect was linked to increased levels of satiety hormones (PYY and GLP-1) and reduced inflammation. While promising, this is animal research, so human application requires further validation.
AXOS supplementation induced caecal and colon enlargement associated with an important bifidogenic effect. It increased the level of circulating satietogenic peptides produced by the colon (peptide YY and glucagon-like peptide-1), and coherently counteracted HF-induced body weight gain and fat mass development.
Why this rating
The study is conducted on mice, not humans, limiting direct applicability to human weight loss claims.
Source
Wheat-derived arabinoxylan oligosaccharides with prebiotic effect increase satietogenic gut peptides and reduce metabolic endotoxemia in diet-induced obese mice
Audrey M. Neyrinck et al. · Nutrition and Diabetes · 2012
DOI 10.1038/nutd.2011.24
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