Research
Hormonal
AXOS supplementation improves gut barrier function and reduces metabolic endotoxemia in obese mice by upregulating tight junction proteins (ZO1 and claudin 3).
AXOS may help improve gut barrier integrity in obese individuals, potentially reducing inflammation associated with high-fat diets. This is based on mouse models and requires human confirmation.
ModerateSupportsMEDIUM confidence
The tight junction proteins (zonula occludens 1 and claudin 3) altered upon HF feeding were upregulated by AXOS treatment suggesting that the lower inflammatory tone was associated with the improvement of gut barrier function.
Why this rating
Animal study with specific molecular markers.
Source
Wheat-derived arabinoxylan oligosaccharides with prebiotic effect increase satietogenic gut peptides and reduce metabolic endotoxemia in diet-induced obese mice
Audrey M. Neyrinck et al. · Nutrition and Diabetes · 2012
DOI 10.1038/nutd.2011.24
mechanism_only · n=24Cited 221×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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