Micronutrients & recovery
Vitamin D and 4-pyridoxic acid (Vitamin B6 metabolite) levels are significantly lower in the luteal and periovulatory phases, potentially increasing susceptibility to mood disorders like PMS by limiting neurotransmitter synthesis precursors.
Vitamin D and Vitamin B6 (as 4-pyridoxic acid) levels drop during the luteal and periovulatory phases. Since these vitamins are cofactors for neurotransmitter synthesis (serotonin, GABA), this drop may contribute to PMS/PMDD symptoms. Ensuring adequate intake of these nutrients, particularly during the second half of the cycle, may support mental health.
Vitamin D (25-OH vitamin D) showed significant decreases in L-F, L-M and O-M with L-M and O-M and met the multiple testing threshold q < 0.20... Pyridoxic acid also showed an elevation in the menstrual compared to the periovulatory phases (q < 0.20)... The periovulatory reduction in 4-pyridoxic acid may lead to the cystathionine depletion observed in the luteal phase as B6 is a cofactor for the cystathione-β−synthase conversion to cystationine
Why this rating
Strong observational data with FDR correction, linking specific vitamins to phase changes.
Source
Menstrual cycle rhythmicity: metabolic patterns in healthy women
Colleen Fogarty Draper et al. · Scientific Reports · 2018
DOI 10.1038/s41598-018-32647-0
Related findings · Micronutrients & recovery
- Trans fats (industrial trans-fatty acids) are unequivocally harmful and should be completely avoided as they raise LDL-C, TGs, and Apo B while lowering HDL-C.Strong
- For menopausal women with osteoporosis, first-line pharmacologic therapies include alendronate, risedronate, zoledronic acid, and denosumab for the prevention of hip, nonvertebral, and vertebral fractures.Strong
- Folic acid fortification of flour prevents neural tube birth defects, and mandatory fortification is more effective than voluntary supplementation alone.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →