Mixed
Oxidative stress, driven by excessive reactive oxygen species (ROS) from both endogenous (mitochondrial dysfunction, NOX activity) and exogenous (air pollution, UV, smoking) triggers, is a central causal mechanism in cellular senescence and the pathogenesis of aging-related diseases including neurodegeneration, cardiovascular disease, and cancer.
Aging and many chronic diseases are linked to cellular damage from oxidative stress. You can mitigate this by reducing exposure to external triggers like air pollution, UV radiation, and smoking, and by maintaining healthy lifestyle habits such as regular exercise and a balanced diet rich in antioxidants, which help manage internal ROS levels.
OS plays a central role in the onset and development of aging and related diseases. Persistent OS not only accelerates the aging process of the body but also further induces the occurrence of aging-related diseases by damaging important cell structures such as mitochondria, DNA, and telomeres.
Why this rating
This is a review paper citing numerous studies; while not a single RCT, the consensus across multiple disease models is strong.
Source
Progress in Understanding Oxidative Stress, Aging, and Aging-Related Diseases
Jianying Yang et al. · Antioxidants · 2024
DOI 10.3390/antiox13040394
Related findings · Mixed
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