Micronutrients & recovery
Nicotinamide Riboside (NR) supplementation at doses up to 1000 mg/day for 8 weeks significantly increases whole blood NAD+ levels in a dose-dependent manner without causing flushing or elevating LDL cholesterol in healthy overweight adults.
If you are looking to boost NAD+ levels, taking Nicotinamide Riboside (NR) between 100mg and 1000mg daily for 8 weeks is a safe and effective strategy for healthy overweight adults. You can expect a significant increase in blood NAD+ (up to 140% at the highest dose) without the flushing side effects of Niacin or negative impacts on cholesterol. Start with a lower dose (100-300mg) to assess tolerance, though the study found all doses well-tolerated.
Consumption of 100, 300 and 1000 mg NR dose-dependently and significantly increased whole blood NAD+ (i.e., 22%, 51% and 142%) and other NAD+ metabolites within 2 weeks. The increases were maintained throughout the remainder of the study. There were no reports of flushing and no significant differences in adverse events between the NR and placebo-treated groups or between groups at different NR doses. NR also did not elevate low density lipoprotein cholesterol or dysregulate 1-carbon metabolism.
Why this rating
Randomized, double-blind, placebo-controlled clinical trial with 140 participants, though short duration (8 weeks) and specific population (overweight, healthy).
Source
Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults
Dietrich B. Conze et al. · Scientific Reports · 2019
DOI 10.1038/s41598-019-46120-z
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