Mixed
A 76-protein plasma proteomic signature of age (PROage) and its derived measure of biological age acceleration (PROaccel) predict the accumulation of chronic diseases (multimorbidity) and all-cause mortality independent of chronological age.
Your chronological age is not your destiny. This research identifies a specific set of 76 proteins in your blood that act as a 'biological clock.' If your biological age (calculated from these proteins) is higher than your actual age, you are at significantly higher risk for developing multiple chronic diseases and dying earlier. This test can identify 'fast-agers' who may benefit from early, intensive lifestyle or medical interventions to slow down this biological acceleration, rather than waiting for symptoms to appear.
A 76-protein proteomic age signature predicted accumulation of chronic diseases and all-cause mortality. ... Having a positive PROaccel would indicate that the individual is older than their chronological age based on proteomic data. ... In subjects over 65 years, there was an average increase of 0.21 comorbid diseases per year in fast-agers compared to slow-agers.
Why this rating
Large cohort (N=997), long follow-up (18 years), replication in independent cohorts (BLSA, INTERVAL), and Mendelian randomization support causal links for specific proteins.
Source
Plasma proteomic biomarker signature of age predicts health and life span
Toshiko Tanaka et al. · eLife · 2020
DOI 10.7554/elife.61073
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