Research
Hormonal
MCP-1 (CCL2) secretion from hypertrophied adipocytes recruits monocytes to adipose tissue, leading to M1 macrophage infiltration and insulin resistance.
High levels of MCP-1 in fat tissue act as a beacon, pulling inflammatory cells into fat. Reducing MCP-1 levels might help prevent this inflammatory infiltration.
GoodSupportsHIGH confidence
MCP-1 secreted from enlarged adipocytes attracted circulating monocytes to adipose tissue, causing inflammatory characteristics of adipose tissue.
Why this rating
Supported by multiple studies cited in the review.
Source
Recent Advances in Obesity-Induced Inflammation and Insulin Resistance
Sanshiro Tateya et al. · Frontiers in Endocrinology · 2013
DOI 10.3389/fendo.2013.00093
narrative_reviewCited 210×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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