Mixed
Aging is characterized by a significant decline in adaptive homeostasis capacity, specifically the inability to transiently expand or contract homeostatic ranges in response to sub-toxic stressors, leading to increased susceptibility to damage and mortality.
As you age, your body's ability to bounce back from minor stressors (like mild exercise or dietary changes) diminishes. This isn't just about damage accumulation; it's about losing the signaling capacity to adapt. To maintain healthspan, focus on avoiding chronic, repetitive stressors rather than seeking constant 'hormetic' spikes, as your adaptive reserves are likely compressed.
In this review, we present the hypothesis that one hallmark of the ageing process is a significant decline in adaptive homeostasis capacity.
Why this rating
Supported by multiple model organisms (worms, flies, mice, humans) and cell culture studies.
Source
The role of declining adaptive homeostasis in ageing
Laura C.D. Pomatto et al. · The Journal of Physiology · 2017
DOI 10.1113/jp275072
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