Hormonal
Younger age is a significant predictor of regression from pre-diabetes to normal glucose regulation, likely due to better preserved insulin secretion and sensitivity.
Younger age is associated with a higher likelihood of reversing pre-diabetes, largely because younger people tend to have better insulin secretion and sensitivity. However, this does not mean older adults cannot benefit. Lifestyle interventions (diet and exercise) are still effective for older adults, though they may need to work harder to overcome age-related biological declines. The best strategy is to establish healthy habits early.
Younger age (1.07, P < 0.01)... predicted regression to NGR... Insulin secretion, and other biologic processes retained with younger age, are key in restoring NGR.
Why this rating
Derived from the same high-quality RCT (DPP).
Source
Regression From Pre-Diabetes to Normal Glucose Regulation in the Diabetes Prevention Program
Leigh Perreault et al. · Diabetes Care · 2009
DOI 10.2337/dc09-0523
More from this paper
- Intensive lifestyle modification (ILS) significantly increases the likelihood of regression from pre-diabetes to normal glucose regulation (NGR) compared to placebo, with effects driven by both weight loss and non-weight-loss components of the intervention.Strong
- Higher baseline insulin secretion is a key biological predictor of regression from pre-diabetes to normal glucose regulation, suggesting that preserving beta-cell function is critical for reversal.Strong
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