Mixed
Young men with newly diagnosed fatty liver exhibit impaired left ventricular energy metabolism (reduced PCr/ATP ratio) and increased mediastinal fat, despite having normal left ventricular morphology and systolic/diastolic function.
If you have been diagnosed with fatty liver, even if you are young, fit, and have normal blood pressure and standard heart function tests, your heart's energy efficiency may already be compromised. This metabolic shift happens before your heart shows signs of failure on standard exams. Addressing the underlying metabolic drivers (like insulin resistance and visceral fat) is critical to prevent long-term cardiac remodeling.
In conclusion, in newly found individuals with fatty liver, fat was accumulated in the epicardial area and despite normal LV morphological features and systolic and diastolic functions, they had abnormal LV energy metabolism.
Why this rating
High-quality observational study with rigorous matching (age, BMI, lifestyle) and advanced non-invasive imaging (31P-MRS, MRI), though cross-sectional design limits causal inference.
Source
Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver
Gianluca Perseghin et al. · Hepatology · 2007
DOI 10.1002/hep.21983
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