Resveratrol (150 mg/day) increases energy expenditure and reduces inflammatory markers in obese men, but higher doses (1500 mg/day) may be ineffective for these outcomes.

In a randomized double-blind cross-over study, Timmers et al. showed that 150 mg/day of resveratrol treatment increased energy expenditure, reduced serum inflammatory markers, and decreased adipose tissue lipolysis and plasma fatty acid and glycerol levels of obese men [101]. However, another report showed that high levels of resveratrol supplementation treatment had no effect on energy expenditure, adipose tissue content, and metabolic events [103]. The reason for the reversed results obtained from the two reports may possibly lie in the administered doses of resveratrol they used for obesity treatment. The latter report used 1500 mg/day for the trial [103]; this dose was ten times of the dose Konings et al. used in the study [102].