Research
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Activation of AMPK by dietary restriction or compounds like metformin extends lifespan by inhibiting mTOR and promoting mitochondrial biogenesis.
Dietary restriction activates AMPK, which improves mitochondrial health and extends lifespan. If strict dieting is not feasible, compounds like metformin (which activate AMPK) or time-restricted eating may offer similar metabolic benefits.
GoodSupportsHIGH confidence
Long-term and acute DR activates AMPK... Like rapamycin, a key outcome of both DR and activated AMPK is the inhibition and suppression of mTOR signaling... AMPK regulates mitochondrial biogenesis by controlling the expression of mitochondrial genes.
Why this rating
Strong evidence from model organisms and known effects of metformin/DR in humans.
Source
Mitochondria in the signaling pathways that control longevity and health span
Mansour Akbari et al. · Ageing Research Reviews · 2019
DOI 10.1016/j.arr.2019.100940
narrative_reviewCited 207×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Inhibition of the Insulin/IGF-1 Signaling (IIS) pathway extends lifespan in multiple species by enhancing mitochondrial function, biogenesis, and mitophagy.Good
- Inhibition of mTORC1 by rapamycin extends lifespan in multiple species by enhancing autophagy and mitophagy, thereby maintaining mitochondrial homeostasis.Good
- Mild mitochondrial stress and modest increases in mitochondrial ROS levels increase lifespan in C. elegans, demonstrating that ROS acts as a beneficial signaling molecule rather than solely as a damaging agent.Moderate
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