Energy balance

Gut microbiota depletion via broad-spectrum antibiotics significantly reduces skeletal muscle endurance and fatigue resistance in healthy mice, an effect mediated by altered glucose homeostasis and muscle glycogen levels rather than changes in muscle mass or mitochondrial function.

Maintaining a healthy gut microbiome is important for muscle endurance. While this study used mice, it suggests that factors disrupting gut bacteria (like broad-spectrum antibiotics) may temporarily reduce your stamina and fatigue resistance. Restoring gut health (natural reseeding) can reverse these effects. Focus on fiber-rich foods and fermented foods to support gut bacteria, which may help optimize glucose availability for your muscles during exercise.