Mixed
Accumulation of Persistent Organic Pollutants (POPs) in adipose tissue is associated with a metabolically unhealthy obesity phenotype, suggesting that environmental toxins may drive metabolic dysfunction and inflammation.
Reducing body fat may help lower your body burden of environmental toxins stored in adipose tissue. Prioritize a diet low in highly processed foods and high-fat animal products, which can be sources of certain POPs, and maintain a healthy weight to minimize the reservoir for these metabolic disruptors.
Gauthier et al. demonstrated the relationship of POPs with the variation in metabolic risk observed among obese individuals showing that the MHO phenotype is associated with lower plasma levels of POPs as compared with MUO subjects [156].
Why this rating
Based on observational studies and mechanistic animal models cited in a review; causality in humans is suggested but not definitively proven by randomized trials.
Source
Metabolically Healthy Obesity—Heterogeneity in Definitions and Unconventional Factors
Inês Brandão et al. · Metabolites · 2020
DOI 10.3390/metabo10020048
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