Macro partitioning
Fecal microbiota transplantation (FMT) from lean, insulin-sensitive donors can significantly improve insulin sensitivity in insulin-resistant obese men within 6 weeks.
FMT from lean donors shows promise for improving insulin sensitivity in obese men, but it is not a guaranteed fix for everyone. This is a complex medical intervention. Current evidence suggests that dietary changes and lifestyle modifications are more accessible and foundational steps to support a healthy microbiome.
It has been demonstrated that stool transplant from a lean, insulin-sensitive donor to insulin-resistant obese men showed that insulin sensitivity of a subset of participants was significantly improved 6 weeks after the transplant (94).
Why this rating
Based on a specific human study cited (ref 94), but the text notes it works in a 'subset' of participants, indicating variability.
Source
Gut Microbiota, Host Organism, and Diet Trialogue in Diabetes and Obesity
Veronica Lazăr et al. · Frontiers in Nutrition · 2019
DOI 10.3389/fnut.2019.00021
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