Research
Energy balance
Decreased mitochondrial biogenesis and dysregulated lipid oxidation lead to compromised skeletal muscle bioenergetic status (low ATP) and muscle wasting in early critical illness.
Early muscle loss in the ICU is driven by a failure of the muscle's energy factories (mitochondria) to produce ATP, not just by lack of movement. This metabolic shutdown prevents recovery even if nutrition is provided.
GoodSupportsHIGH confidence
Decreased mitochondrial biogenesis and dysregulated lipid oxidation contribute to compromised skeletal muscle bioenergetic status... network analysis revealed a close and direct relationship between bioenergetic impairment and reduction in muscle mass
Why this rating
Strong observational data with serial biopsies, metabolomics, and network analysis linking molecular changes to clinical outcomes.
Source
Metabolic phenotype of skeletal muscle in early critical illness
Zudin Puthucheary et al. · Thorax · 2018
DOI 10.1136/thoraxjnl-2017-211073
cohort · n=63Cited 204×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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