Energy balance
In individuals with type 2 diabetes, hepatic energy metabolism (specifically ATP and inorganic phosphate concentrations) is impaired and correlates with hepatic insulin resistance, independent of liver fat content.
For those with Type 2 Diabetes, liver health involves more than just fat storage; it involves cellular energy production. Research indicates that even when liver fat levels are similar to non-diabetics, people with T2DM have significantly lower levels of cellular energy (ATP) in the liver, which drives insulin resistance. This suggests that supporting mitochondrial health and energy metabolism is a key target for managing T2DM, potentially preceding or existing independently of visible liver fat.
These data suggest that impaired hepatic energy metabolism and insulin resistance could precede the development of steatosis in individuals with T2DM.
Why this rating
Controlled clinical study with rigorous measurement (MRS) and statistical adjustment for confounders.
Source
Abnormal Hepatic Energy Homeostasis in Type 2 Diabetes†
Julia Szendroedi et al. · Hepatology · 2009
DOI 10.1002/hep.23093
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