Hormonal
Interleukin-6 (IL-6) secreted by brown adipose tissue is required for the insulin-sensitizing effects of BAT transplantation, acting as a key 'batokine'.
This finding highlights the complexity of metabolic signaling. While exercise and cold exposure increase IL-6, its source and context determine its effect. BAT-derived IL-6 improves insulin sensitivity, whereas chronic elevation in obesity may contribute to resistance. Focus on activating BAT through cold exposure to harness these beneficial hormonal effects.
the improved metabolic profile was lost when BAT used for transplantation came from IL-6 knockout mice, clearly demonstrating that BAT-derived IL-6 is required for the profound effects of BAT transplantation on glucose homeostasis and insulin sensitivity.
Why this rating
Based on rodent transplantation studies showing loss of effect without IL-6.
Source
Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance
Anne-Laure Poher et al. · Frontiers in Physiology · 2015
DOI 10.3389/fphys.2015.00004
More from this paper
- Activation of brown adipose tissue (BAT) via cold exposure, beta-3 agonists, or specific hormonal mediators (FGF21, IL-6, BMPs) improves glucose tolerance and insulin sensitivity in humans and rodents.Good
- Chronic cold acclimation increases the volume and oxidative capacity of metabolically active brown adipose tissue in humans, leading to increased energy expenditure and improved insulin sensitivity.Good
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