Research
Macro partitioning
Consumption of arachidonic acid (AA) and saturated fatty acids (SFAs) increases pro-inflammatory gene expression, specifically upregulating IL-8, IL-6, and TNF-alpha in adipocytes and peripheral blood mononuclear cells (PBMCs).
Be mindful of the types of fats you eat. Diets high in arachidonic acid (found in eggs, dairy, red meat) and saturated fats can trigger inflammatory gene expression. Prioritize anti-inflammatory fats like Omega-3s and monounsaturated fats to mitigate this response.
GoodSupportsHIGH confidence
Arachidonic acid and saturated fatty acids (SFAs) both demonstrate an ability to increase pro-inflammatory IL-8 along with numerous other inflammatory factors including IL-6, TNF𝛼, IL-1𝛽, and CXCL1 for arachidonic acid and IGB2 and CTSS for SFA.
Why this rating
Supported by multiple human intervention studies and microarray data cited in the review.
Source
Nutritionally Mediated Oxidative Stress and Inflammation
Alexandra Muñoz et al. · Oxidative Medicine and Cellular Longevity · 2013
DOI 10.1155/2013/610950
narrative_reviewCited 203×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
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