Research
Energy balance
Caloric restriction downregulates inflammatory gene expression in adipose tissue and PBMCs, including markers like IL-6, IL-8, and TNF-related proteins, often requiring sustained periods (e.g., 28 days) to observe significant changes.
Sustained caloric restriction is a powerful tool for reducing inflammation. Focus on maintaining a caloric deficit for at least several weeks to see significant downregulation of inflammatory genes in fat tissue and blood cells.
GoodSupportsHIGH confidence
Obese women undergoing intense caloric restriction for 28 days exhibited an improvement in the inflammatory profile of 100 transcripts in subcutaneous adipose tissue, including downregulation of inflammatory markers including acute phase reactants and TNF-related proteins...
Why this rating
Supported by microarray studies and human intervention trials.
Source
Nutritionally Mediated Oxidative Stress and Inflammation
Alexandra Muñoz et al. · Oxidative Medicine and Cellular Longevity · 2013
DOI 10.1155/2013/610950
narrative_reviewCited 203×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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