Research
Micronutrients & recovery
Supplementation with Nicotinamide Mononucleotide (NMN) increases SIRT1, PGC-1α, and leptin expression while reducing pro-fibrotic collagens in a SIRT1-dependent manner.
NMN supplementation in cell models boosts metabolic health markers like leptin and mitochondrial function via SIRT1. However, translating the 1 mM cell culture dose to humans is not direct, and clinical efficacy remains to be fully established.
ModerateSupportsMEDIUM confidence
Supplementing preadipocytes with the NAD+ booster nicotinamide mononucleotide (NMN) during differentiation increased expression levels of leptin, SIRT1, and PGC-1α and its transcriptional targets, and reduced levels of pro-fibrotic collagens (Col6A1 and Col6A3) in a SIRT1-dependent manner.
Why this rating
In vitro study; clear dose-response relationship observed.
Source
SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways
Yasser Majeed et al. · Scientific Reports · 2021
DOI 10.1038/s41598-021-87759-x
mechanism_onlyCited 201×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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