Research
Mixed
Lean NAFLD is a distinct phenotype characterized by visceral adiposity and metabolic abnormalities despite normal BMI, and it carries similar cardio-metabolic risks to obese NAFLD.
Being lean does not protect you from fatty liver. If you have visceral fat (belly fat) despite a normal weight, you are at risk for NAFLD and its complications. Focus on reducing visceral fat through exercise and diet, and get screened if you have risk factors like family history or metabolic issues.
GoodQualifiesHIGH confidence
Lean NAFLD cases have been described among different ethnic population... these individuals develop IR and atherogenic dyslipidemia similarly to obese patients
Why this rating
Supported by epidemiological data and genetic studies cited.
Source
Nonalcoholic fatty liver disease: Evolving paradigms
Amedeo Lonardo et al. · World Journal of Gastroenterology · 2017
DOI 10.3748/wjg.v23.i36.6571
narrative_reviewCited 199×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Nonalcoholic fatty liver disease (NAFLD) is a systemic condition with multifactorial pathogenesis, not merely a hepatic manifestation of metabolic syndrome, and it can precede the development of metabolic syndrome and type 2 diabetes.Good
- Genetic variants, specifically PNPLA3 I148M and TM6SF2 E167K, significantly increase the risk of liver disease progression and hepatocellular carcinoma in NAFLD patients, independent of metabolic syndrome severity.Good
Related findings · Mixed
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