Micronutrients & recovery
Plasma levels of NAD+ and NADP+ significantly decline with age, while levels of their reduced forms (NADH, NADPH) and catabolites (NAM, MeNAM, ADPR) increase, indicating a dysregulated NAD+ metabolome in normal aging.
This study confirms that NAD+ levels drop significantly as you age, which is linked to cellular energy and repair issues. While this paper doesn't prescribe a fix, it highlights that this decline is a key feature of aging and suggests that maintaining or boosting NAD+ levels (e.g., through precursors like NR or NMN, as mentioned in references) might be a viable strategy for healthspan.
Our data show a significant decline in the plasma levels of NAD+, NADP+, and other important metabolites such as nicotinic acid adenine dinucleotide (NAAD) with age. However, an age-related increase in the reduced form of NAD+ and NADP+—NADH and NADPH—and nicotinamide (NAM), N-methyl-nicotinamide (MeNAM), and the products of adenosine diphosphoribosylation, including adenosine diphosphate ribose (ADPR) was also reported.
Why this rating
Cross-sectional observational study with a relatively small sample size (n=30) and no intervention.
Source
The Plasma NAD <sup>+</sup> Metabolome Is Dysregulated in “Normal” Aging
James P. Clement et al. · Rejuvenation Research · 2018
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