Research
Micronutrients & recovery
High-dose phenolic compound supplementation can exhibit pro-oxidant effects and cause toxicity, including liver damage and accelerated tumorigenesis, in certain contexts.
Avoid high-dose polyphenol supplements. While dietary sources are safe, concentrated supplements can become pro-oxidant and cause liver stress or other toxic effects.
GoodRefutesHIGH confidence
The literature has documented that PCs exhibit toxic pro-oxidative effects at high concentrations... Several clinical studies showed that taking antioxidant supplements, including vitamins A, C, and E, as well as β-carotene and PCs, can accelerate tumorigenesis.
Why this rating
Cites specific clinical studies and observed toxic effects like increased serum transaminase and bilirubin.
Source
Antioxidative properties of phenolic compounds and their effect on oxidative stress induced by severe physical exercise
Joanna Kruk et al. · The Journal of Physiological Sciences · 2022
DOI 10.1186/s12576-022-00845-1
narrative_reviewCited 198×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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