Research
Mixed
Downregulation of ribosomal proteins and ribosome biogenesis factors is a conserved hallmark of cellular ageing, likely serving as a protective programme rather than a cause of pathology.
Aging involves a reduction in the genetic instructions for building ribosomes. This is not a defect but a protective mechanism. Interventions that extend lifespan, such as caloric restriction and rapamycin, also reduce these levels, suggesting that this downregulation is beneficial for longevity.
GoodSupportsHIGH confidence
Together, these data suggest that down-regulation of ribosome components and ribosome biogenesis factors is a highly conserved hallmark of ageing... Many lines of evidence suggest that this down-regulation is a protective programme aimed at mitigating age-linked pathology.
Why this rating
Supported by large cohort studies, meta-analyses in humans, and cross-species data.
Source
Gene expression hallmarks of cellular ageing
Stephen Frenk et al. · Biogerontology · 2018
DOI 10.1007/s10522-018-9750-z
narrative_reviewCited 198×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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