Research
Adherence
Carriers of the ADRB2 Gln27Glu polymorphism, particularly females, face a significantly higher obesity risk associated with sedentary behavior (high TV watching time), and may not benefit from reducing sedentary time as much as non-carriers.
For females with the ADRB2 Glu27 variant, minimizing time spent watching TV is especially important. They may have a higher baseline risk from sedentary behavior and might not see the same obesity risk reduction from cutting screen time as others.
GoodQualifiesHIGH confidence
These results suggest that carriers of the 27Glu allele of the ADRB2 gene may not benefit from a reduction in sedentary behaviour as much as the subjects who do not carry the polymorphism.
Why this rating
Based on case-control studies in children/adolescents with adjusted odds ratios.
Source
Interaction between genes and lifestyle factors on obesity
Amelia Martí et al. · Proceedings of The Nutrition Society · 2008
DOI 10.1017/s002966510800596x
narrative_reviewCited 196×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Carriers of the ADRB2 Gln27Glu polymorphism experience increased obesity risk when consuming high carbohydrate diets (>49% total energy), whereas non-carriers do not show this specific dietary interaction.Good
- Carriers of the ADRB3 Trp64Arg polymorphism have a significantly higher risk of obesity when engaging in low levels of physical activity, but this risk is not apparent in active subjects.Good
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