Research
Energy balance
Carriers of the ADRB3 Trp64Arg polymorphism have a significantly higher risk of obesity when engaging in low levels of physical activity, but this risk is not apparent in active subjects.
If you carry the ADRB3 Trp64Arg variant, maintaining regular physical activity is crucial to mitigating your obesity risk. Sedentary behavior significantly amplifies your genetic risk, but being active appears to neutralize it.
GoodConditionalHIGH confidence
An effect modification across recreational physical activity strata was apparent, and a univariate OR of 2.98 (95 % CI 1.00, 8.56) was found within the sedentary group (low physical activity; M/S< 0.5) whereas no increment in risk was apparent for active subjects (high physical activity; M/S >0.5).
Why this rating
Based on case-control studies with adjusted odds ratios.
Source
Interaction between genes and lifestyle factors on obesity
Amelia Martí et al. · Proceedings of The Nutrition Society · 2008
DOI 10.1017/s002966510800596x
narrative_reviewCited 196×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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