Energy balance
Genetic overexpression of SIRT6 extends median and maximal lifespan in both male and female C57BL/6 mice by preserving hepatic gluconeogenesis and energy homeostasis during aging.
This research identifies SIRT6 as a key regulator of healthy aging in mice, specifically by maintaining the liver's ability to produce glucose (gluconeogenesis) from precursors like lactate and glycerol during fasting. This prevents the metabolic decline and frailty associated with aging. While this is a genetic model, it suggests that supporting metabolic flexibility and hepatic health may be crucial for longevity. For humans, this underscores the importance of maintaining metabolic health through regular physical activity and potentially time-restricted eating patterns that engage gluconeogenic pathways, rather than seeking a simple genetic fix.
SIRT6 overexpression in C57BL/6 mice led to a 27% and 15% extension in median lifespan, in males and females, respectively... SIRT6 overexpression leads to a reduction in frailty and lifespan extension in both male and female B6 mice.
Why this rating
High-quality in vivo murine study with multi-omics validation, though translational to humans is not directly tested.
Source
Restoration of energy homeostasis by SIRT6 extends healthy lifespan
Asael Roichman et al. · Nature Communications · 2021
DOI 10.1038/s41467-021-23545-7
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