Hormonal
Metformin administration (1,700 mg/day) blunts gains in lean body mass and thigh muscle mass in older adults undergoing progressive resistance training.
If you are over 65 and taking metformin, expect less muscle gain from resistance training compared to someone not taking it. This is likely due to how metformin affects cellular signaling (mTOR/AMPK). Do not stop your medication without medical advice, but adjust your expectations for muscle growth.
Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults... placebo gained more lean body mass (p = .003) and thigh muscle mass (p < .001) than metformin.
Why this rating
Randomized, double-blind, placebo-controlled, multicenter trial with a large sample size (N=94) and statistically significant results.
Source
Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double‐blind, placebo‐controlled, multicenter trial: The MASTERS trial
R. Grace Walton et al. · Aging Cell · 2019
DOI 10.1111/acel.13039
More from this paper
- Metformin blunts increases in thigh muscle area and density resulting from progressive resistance training in older adults.Strong
- Metformin does not affect muscle fiber hypertrophy (cross-sectional area) or satellite cell abundance in response to progressive resistance training in older adults.Strong
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