Research
Mixed
Elevated plasma TMAO levels are associated with a higher risk of recurrent ASCVD in individuals with preexisting cardiovascular disease, independent of renal function status.
If you have a history of heart disease, higher TMAO levels are linked to a higher risk of another heart event. This risk exists regardless of your kidney function. Discussing TMAO levels with your cardiologist may help tailor your prevention strategy.
GoodSupportsHIGH confidence
Among individuals with prior ASCVD, TMAO associated with higher risk of recurrent ASCVD (HR, 1.25 [95% CI, 1.01– 1.56]; P- trend=0.009), without significant modification by eGFR.
Why this rating
Prospective cohort with serial measures and central adjudication, though observational.
Source
Longitudinal Plasma Measures of Trimethylamine N‐Oxide and Risk of Atherosclerotic Cardiovascular Disease Events in Community‐Based Older Adults
Yujin Lee et al. · Journal of the American Heart Association · 2021
DOI 10.1161/jaha.120.020646
cohort · n=4131Cited 87×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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