Research
Macro partitioning
Dietary fiber from the Mediterranean Diet reduces colorectal cancer risk by decreasing systemic inflammation, modulating gut microbiota, and reducing contact time of carcinogens with the intestinal epithelium.
Increase your intake of dietary fiber through whole grains, legumes, fruits, and vegetables. This helps feed beneficial gut bacteria, reduces systemic inflammation, and may lower your risk of colorectal cancer.
GoodSupportsHIGH confidence
The high presence of fiber typical of the MD is probably at the basis of the reduced incidence of colorectal cancer. Dietary fibers possess a proven anti-inflammatory action decreasing systemic inflammation-associated biomarkers such as CRP, IL-6, and TNF-α... Fermentable dietary fibers shift the gut microbial populations... and these changes in gut flora population can result in a modulation of inflammatory processes.
Why this rating
Strong observational and mechanistic evidence, though specific dose-response in humans is less defined than in MD adherence.
Source
Inflammaging and Cancer: A Challenge for the Mediterranean Diet
Rita Ostan et al. · Nutrients · 2015
DOI 10.3390/nu7042589
narrative_reviewCited 194×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Adherence to the Mediterranean Diet (MD) significantly reduces the overall risk of cancer incidence and mortality by approximately 10% through the modulation of chronic low-grade systemic inflammation (inflammaging).Good
- Polyphenols found in the Mediterranean Diet (e.g., from olive oil and red wine) reduce cancer risk by inhibiting inflammatory pathways (NF-κB, COX-2) and modulating signaling molecules (mTOR, sirtuins).Moderate
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