Adherence
A two-year physical activity intervention significantly reduces the Epigenetic Mutation Load (EML) in healthy postmenopausal women.
Increasing your regular recreational physical activity over two years can significantly reduce your Epigenetic Mutation Load, a marker associated with cancer risk and aging. You do not need to be an elite athlete; simply increasing your daily movement has measurable biological benefits.
increasing physical activity led to a significant reduction of SEMs in crucial cancer-related pathways... the PA intervention caused a significant reduction of the delta EML (β = −2.06, 95% CI −2.84 to −1.28, p < 0.0001)
Why this rating
Randomized controlled trial design with a large sample size (N=219) and highly statistically significant results (p < 0.0001).
Source
DNA methylation‐based biomarkers of aging were slowed down in a two‐year diet and physical activity intervention trial: the DAMA study
Giovanni Fiorito et al. · Aging Cell · 2021
DOI 10.1111/acel.13439
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