Mixed
Obese individuals with type 2 diabetes exhibit a distinct gut microbiota signature characterized by increased relative abundance of Firmicutes and decreased abundance of Verrucomicrobia, Bacteroidetes, and Proteobacteria compared to healthy controls.
This research suggests that the specific gut bacteria in obese diabetic patients differ from healthy people, potentially contributing to insulin resistance. While this is an observational snapshot of a specific population, it implies that dietary changes (reducing high-carb/fat intake) and avoiding unnecessary antibiotics might help restore a healthier microbial balance, though this specific study does not test interventions.
In majority of the obese-T2DM samples, the Firmicutes phyla constituted the highest proportion of the bacterial population compared to that in the healthy individuals, with relative abundance of 55.7% and 36.9%, respectively... Moreover, the relative abundance of Verrucomicrobia, Bacteroidetes, Proteobacteria, and Elusimicrobia was less or even completely absent in obese-T2DM patients
Why this rating
Observational study with small sample size (n=60) and low sequencing depth, limiting generalizability.
Source
Analysis of gut microbiota of obese individuals with type 2 diabetes and healthy individuals
Aftab Ahmad et al. · PLoS ONE · 2019
DOI 10.1371/journal.pone.0226372
More from this paper
- The depletion of Verrucomicrobia in obese-T2DM patients is associated with a loss of anti-inflammatory state and improved insulin sensitivity, potentially allowing the growth of pro-inflammatory Proteobacteria.Moderate
- Increased abundance of gram-negative bacteria (Dialister and Allisonella) in obese-T2DM patients is associated with elevated lipopolysaccharide (LPS) levels, which mediates inflammatory response and contributes to insulin resistance.Moderate
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