Research
Hormonal
In diabetic men, exercise training reduces basal hepatic glucose production by 22%, even when insulin sensitivity (peripheral glucose disposal) does not improve.
For diabetic men, exercise may help lower fasting blood sugar by reducing the liver's glucose output, even if it doesn't improve how muscles use insulin. This suggests exercise has hepatic benefits distinct from peripheral insulin sensitivity.
GoodSupportsHIGH confidence
basal hepatic glucose production was reduced by 22% in the diabetic men.
Why this rating
Same rigorous RCT design as N1.
Source
Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men
K. R. Segal et al. · Journal of Applied Physiology · 1991
DOI 10.1152/jappl.1991.71.6.2402
rct · n=26Cited 192×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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