Research
Mixed
Genetic variants, particularly PNPLA3 (rs738409 C>G), are strongly associated with liver steatosis and progression of liver damage, independent of insulin sensitivity and BMI.
If you have a family history of fatty liver, you may have genetic risks. Regular monitoring and healthy lifestyle choices are still important to manage the risk.
GoodSupportsHIGH confidence
They found a strong association between fatty liver and the PNPLA3 variant rs738409 C>G p.I148M... The presence of this variant also implies a major risk of progression of liver damage, independently from the presence of age, gender or other metabolic risk factors such as insulin sensitivity and BMI.
Why this rating
Supported by genome-wide association studies.
Source
Pathophysiological, Molecular and Therapeutic Issues of Nonalcoholic Fatty Liver Disease: An Overview
Simona Marchisello et al. · International Journal of Molecular Sciences · 2019
DOI 10.3390/ijms20081948
narrative_reviewCited 190×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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