Research
Mixed
Combining Caffeine (5 mg/kg) and Ephedrine (1 mg/kg) does not produce an additive or synergistic effect on anaerobic performance compared to taking either substance alone.
Do not combine Caffeine and Ephedrine for anaerobic performance. You will not get a better result than taking Caffeine alone (for endurance) or Ephedrine alone (for early power). The combination adds side effects without adding performance benefits.
GoodRefutesHIGH confidence
However, there was no additive effect or synergism between C and E when taken together.
Why this rating
Based on the same high-quality RCT design as the positive findings.
Source
Effect of caffeine and ephedrine ingestion on anaerobic exercise performance
Douglas G. Bell et al. · Medicine & Science in Sports & Exercise · 2001
DOI 10.1097/00005768-200108000-00024
crossover · n=24Cited 190×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Ephedrine ingestion (1 mg/kg) significantly increases early-phase power output (first 10 seconds) during high-intensity anaerobic exercise (Wingate test) by stimulating the central nervous system rather than skeletal muscle metabolism.Good
- Caffeine ingestion (5 mg/kg) significantly increases time to exhaustion and oxygen deficit during supramaximal anaerobic exercise (MAOD test) by enhancing skeletal muscle metabolism and epinephrine release, rather than just CNS arousal.Good
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