Hormonal

Activation of the CML-RAGE axis in adipose tissue drives obesity-associated inflammation and insulin resistance by dysregulating adipokine expression (increasing pro-inflammatory cytokines and decreasing adiponectin).

This research suggests that obesity-related insulin resistance is driven by a specific molecular loop involving CML and RAGE in fat tissue. While this paper does not prescribe a direct intervention, it implies that reducing the formation of CML (an advanced glycation end product formed via lipid peroxidation) or blocking RAGE could theoretically improve insulin sensitivity. For now, strategies that reduce oxidative stress and lipid peroxidation (often associated with high sugar/fat diets) may indirectly mitigate this pathway.