Hormonal
Obese individuals exhibit significantly lower plasma CML levels compared to lean individuals, a phenomenon attributed to the trapping of CML in adipose tissue via RAGE.
Standard blood tests for CML (a marker of glycation/oxidative stress) may underestimate the total body burden of these compounds in obese individuals because the compounds are trapped in fat tissue. This trapping mechanism contributes to local inflammation and insulin resistance. Weight loss (bariatric surgery) was shown to increase plasma CML, suggesting that reducing fat mass releases this trapped burden back into circulation.
plasma protein–bound CML concentrations were significantly lower in obese when compared with those in lean subjects... RAGE-mediated trapping in adipose tissue provides a mechanism underlying CML accumulation in adipose tissue and explaining decreased CML plasma levels in obese subjects.
Why this rating
Consistent findings across human biopsies, plasma assays, and mouse trapping experiments.
Source
N <sup>ε</sup> -(Carboxymethyl)lysine-Receptor for Advanced Glycation End Product Axis Is a Key Modulator of Obesity-Induced Dysregulation of Adipokine Expression and Insulin Resistance
Katrien H.J. Gaens et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2014
DOI 10.1161/atvbaha.113.302281
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