Research
Hormonal
CNTF analog CNTFAx15 can induce anorexia and activate mTORC1 signaling even in states of leptin resistance caused by high-fat diets.
This study shows that a specific cytokine analog (CNTFAx15) can reduce food intake in obese animals even when they are resistant to the natural hormone leptin. This suggests that targeting specific brain pathways (like mTORC1) might be a viable strategy for treating obesity where standard hormonal signals fail.
GoodSupportsHIGH confidence
CNTF and its analog CNTFAx15 activate leptin-like pathways in the hypothalamus, even in leptin-resistant states, including diet-induced obesity.
Why this rating
Strong experimental evidence in rodent models showing behavioral and molecular effects.
Source
The Role of Hypothalamic Mammalian Target of Rapamycin Complex 1 Signaling in Diet-Induced Obesity
Daniela Cota et al. · Journal of Neuroscience · 2008
DOI 10.1523/jneurosci.1389-08.2008
mechanism_onlyCited 188×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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