Research
Hormonal
Functional S6K1 is required for the anorectic effects of both leptin and CNTFAx15.
This finding highlights that the brain's ability to process appetite-suppressing signals depends on a specific protein (S6K1). If this protein is not functioning, common appetite-regulating hormones like leptin cannot work effectively.
StrongSupportsVERY_HIGH confidence
mice lacking the expression of S6K1 (S6K1 -/-) did not respond to the anorectic action of either leptin or CNTFAx15, implying a crucial role for S6K1 in modulating the actions of these two cytokines.
Why this rating
Genetic knockout model provides definitive causal evidence for the role of S6K1.
Source
The Role of Hypothalamic Mammalian Target of Rapamycin Complex 1 Signaling in Diet-Induced Obesity
Daniela Cota et al. · Journal of Neuroscience · 2008
DOI 10.1523/jneurosci.1389-08.2008
mechanism_onlyCited 188×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →