Hormonal
Long-term DHEA replacement (50 mg/day) in patients with primary adrenal insufficiency reverses bone mineral density loss at the femoral neck and increases total and truncal lean mass without changing fat mass.
If you have Addison's disease, your body doesn't make enough DHEA. Taking 50mg of DHEA daily for a year can help stop bone loss in your hip and build muscle mass without adding fat. This is a specific medical treatment for a specific deficiency, not a general supplement for healthy people.
DHEA reversed ongoing loss of bone mineral density at the femoral neck (P < 0.05) but not at other sites; DHEA enhanced total body (P < 0.02) and truncal (P < 0.017) lean mass significantly with no change in fat mass.
Why this rating
Randomized, double-blind, placebo-controlled trial with 106 subjects, though limited by specific pathology (Addison's).
Source
Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial
Eleanor Gurnell et al. · The Journal of Clinical Endocrinology & Metabolism · 2007
DOI 10.1210/jc.2007-1134
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