Research
Hormonal
Long-term DHEA replacement (50 mg/day) improves psychological well-being (specifically the 'role emotional' dimension of SF-36) in patients with primary adrenal insufficiency, but does not significantly improve fatigue, cognitive function, or sexual function.
For people with Addison's disease, DHEA might help with emotional well-being and feeling like you can handle daily roles, but don't expect it to fix fatigue or memory problems. It's a targeted treatment for a specific hormonal lack.
GoodQualifiesHIGH confidence
one subscale of SF-36 improved significantly (P < 0.004) after DHEA treatment. There was no significant benefit of DHEA treatment on fatigue or cognitive or sexual function.
Why this rating
RCT design, clear statistical significance for one psychological metric, but null for others.
Source
Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial
Eleanor Gurnell et al. · The Journal of Clinical Endocrinology & Metabolism · 2007
DOI 10.1210/jc.2007-1134
rct · n=106Cited 188×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →