Research

Energy balance

Weight loss (WL) alone reduces glucose and insulin responses during an oral glucose tolerance test (OGTT) but does not improve insulin-mediated glucose disposal measured by hyperinsulinemic euglycemic clamp.

Losing weight through diet alone helps your body handle sugar loads better (improving oral glucose tolerance), but it may not improve how your muscles use insulin as effectively as exercise does. For best metabolic health, combine diet and exercise.

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In contrast, WL alone was associated with decreases in glucose and insulin responses during the glucose tolerance test but with no change in insulin-mediated glucose disposal.
Donald R. Dengel et al. · Journal of Applied Physiology · 1996

Why this rating

RCT with rigorous metabolic clamping, specific to the WL-only arm.

Source

Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men

Donald R. Dengel et al. · Journal of Applied Physiology · 1996

DOI 10.1152/jappl.1996.81.1.318

rct · n=47Cited 188×
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DOI resolved against Crossref · corpus check 2026-06-10

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