Research
Hormonal
Obstructive sleep apnea (OSA) causes oxidative stress through intermittent hypoxia, leading to endothelial dysfunction and increased cardiovascular disease risk.
Untreated OSA creates a cycle of oxygen deprivation that damages blood vessels through oxidative stress, increasing the risk of hypertension and heart disease. Treating OSA is crucial for long-term cardiovascular health.
GoodSupportsHIGH confidence
The main trigger of these metabolic and cellular changes is IH, that is, the nocturnal hypoxia-reoxygenation events accompanying OSA. ... Oxidative stress in OSA correlates with surrogate markers of CV diseases such as endothelial function, intima-media thickness, and high blood pressure.
Why this rating
Based on a review of 36 human studies showing consistent biomarker changes, though some have methodological limitations.
Source
Obstructive Sleep Apnea, Oxidative Stress, and Cardiovascular Disease: Evidence from Human Studies
Hans-Joachim Eisele et al. · Oxidative Medicine and Cellular Longevity · 2015
DOI 10.1155/2015/608438
narrative_reviewCited 187×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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