Research
Mixed
GLP-1 receptor agonists (Liraglutide, Semaglutide) and other weight loss medications produce significant mean weight loss compared to placebo.
If lifestyle changes are insufficient, discuss GLP-1 agonists like Semaglutide or Liraglutide with your doctor. These medications can produce significant weight loss (up to 15% with Semaglutide) by reducing appetite and slowing digestion.
GoodSupportsHIGH confidence
Semaglutide 2.4: Average 15% weight loss over 68 weeks compared to 2.4% loss on placebo... Liraglutide: 4-6 kg weight loss with 25% losing >10% body weight over 56 weeks
Why this rating
Based on RCTs cited in the review.
Source
Weight, Shape, and Body Composition Changes at Menopause
Anna Fenton · Journal of Mid-life Health · 2021
DOI 10.4103/jmh.jmh_123_21
narrative_reviewCited 73×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Regular physical activity (150-300 min moderate or 75-150 min vigorous aerobic activity plus resistance training 2x/week) protects against age-associated weight gain and targets fat and muscle mass respectively.Strong
- Menopause triggers a shift in body composition toward increased visceral and perivascular fat and reduced fat-free mass, independent of modest total weight gain, driven by estrogen deficiency and elevated FSH.Good
- Estrogen replacement therapy (ERT) and progestin therapy reduce BMI, waist circumference, fasting insulin, and the incidence of new diabetes compared to placebo.Good
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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