Mixed
Gut microbiota manipulation via antibiotics, prebiotics, or probiotics improves metabolic parameters (insulin resistance, inflammation, fat mass) in animal models of obesity and NAFLD, though human data remains scarce and inconclusive.
While animal studies show that changing gut bacteria (via antibiotics, prebiotics, or probiotics) can improve metabolic health, human evidence is currently insufficient to recommend these as standard treatments. Focus on a balanced diet to support a healthy microbiome rather than seeking specific microbiota-altering supplements without medical guidance.
Gut microbiota manipulation through antibiotics, prebiotics and probiotics yields encouraging results for the treatment of obesity, diabetes and NAFLD in animal models, but data in humans are currently scarce.
Why this rating
Strong animal data but limited and mixed human trials.
Source
Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: mechanisms and implications for metabolic disorders
Giovanni Musso et al. · Current Opinion in Lipidology · 2010
DOI 10.1097/mol.0b013e3283347ebb
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