Energy balance
Cideb deficiency reduces hepatic lipogenesis by downregulating SREBP1c and its downstream targets (ACC, FAS, SCD1), while simultaneously increasing fatty acid oxidation.
This study identifies Cideb as a key regulator of liver fat balance. By reducing Cideb activity, the liver shifts from storing fat (lipogenesis) to burning it (oxidation). This suggests that therapies targeting Cideb or its regulators (like SREBP1c) could be effective in treating fatty liver disease and obesity by rebalancing these metabolic pathways.
Cideb-null mice showed decreased lipogenesis and reduced expression levels of acetyl-CoA carboxylase, fatty acid synthase, and stearol-CoA desaturase. We further demonstrated that expression levels of sterol response element binding protein 1c was significantly decreased in Cideb-deficient mice... The rate of palmitic acid oxidization in isolated hepatocytes of Cideb-null mice was 30% higher than that of the wild-type mice.
Why this rating
Strong mechanistic evidence with multiple molecular markers and functional assays.
Source
Cideb Regulates Diet-Induced Obesity, Liver Steatosis, and Insulin Sensitivity by Controlling Lipogenesis and Fatty Acid Oxidation
John Li et al. · Diabetes · 2007
DOI 10.2337/db07-0040
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